Mysterious new creatures, servants of the Overlord and the Dragon have joined the armies of Quake, eager to spill some human blood. There exist fifteen new monsters, making up a total of thirty (including the Rotfish).
| Monster | Health | Attack 1 | Damage | Attack 2 | Damage | Attack 3 | Damage |
| Electric Eel | 60 | Electric | 25-30 | - | - | - | - |
| Statue (Knight) | 75 | Sword | 12-18 | Charge | 20-30 | - | - |
| Hell Spawn | 80 | Jump | 11-20 | Explosion | up to 120 | - | - |
| Phantom Swordsman | 150 | Slash | 4-9 | - | - | - | - |
| Multi-Grenade Ogre | 200 | Chainsaw | 35-49 | Multi-Grenades | up to 40 per hit | - | - |
| Statue (D. Knight) | 250 | Sword | 20-36 | Beam | 9-54 | - | - |
| Guardian | 250 | Laser Beam | up to 45 | Staff Butt | 10-20 | - | - |
| Wrath | 400 | Wrath Ball | up to 6 | Death Explosion | up to 60 | - | - |
| Mummy | 1,000 | Gib Throw | up to 29 | - | - | - | - |
| Overlord | 1,000 | Wrath Ball | up to 9 | Axe and Mace | up to 29 | Death Explosion | up to 60 |
| Hephaestus | 1,725 | Fire Ball | up to 40 | - | - | - | - |
| Quake's Guardian | 2,000 | Laser Beam | up to 45 | Staff Butt | 10-20 | - | - |
| Egyptian Guardian | 2,000 | Laser Beam | up to 45 | Staff Butt | 10-20 | - | - |
| Quake's High Priest | 2,000 | Laser Beam | up to 45 | Staff Butt | 10-20 | - | - |
| Dragon | 4,000 (e), 5,000 (n), 6,000 (h) | Fire Breath | up to 80 | Lightning Breath | up to 120 | Claws | up to 30 |